ศาสตราจารย์ ดร. เภสัชกรณรงค์ สาริสุต

คณบดีคณะเภสัชศาสตร์

อาจารย์ประจำสาขาวิชาวิทยาศาสตร์เภสัชกรรม

ศาสตราจารย์ ดร. เภสัชกรณรงค์ สาริสุต

 

คณบดีคณะเภสัชศาสตร์
อาจารย์ประจำสาขาวิชาวิทยาศาสตร์เภสัชกรรม


1. Research and development of drug targeting delivery systems – liposomes
2. Development and manufacture of sustained- and controlled-release drug delivery systems
3. Film coating technology
4. Dissolution technology
5. Stability of Pharmaceuticals

pynst@mahidol.ac.th

ประวัติการศึกษา :

คุณวุฒิ สาขา ปีที่จบ ชื่อสถานศึกษา
ภ.บ. (เกียรตินิยม) เภสัชศาสตร์ 2519 จุฬาลงกรณ์มหาวิทยาลัย
M.S. Pharmaceutics 2522 University of Iowa, USA
Ph.D. Pharmaceutics 2524 University of Iowa, USA

 

ผลงานวิจัยตีพิมพ์ :

1. Sarisuta N, Parrott EL. Comparison of several diffusion equations in the calculation of viscosity and its relation to dissolution rate. Drug Dev Ind Pharm 1982; 8(5): 606-616.
2. Sarisuta N, Parrott EL. Relationship of dissolution rate to viscosity of polymeric solutions. J Pharm Sci 1982; 71(12): 1375-1380.
3. Sarisuta N, Parrott EL. Diffusivity and dissolution rate in polymeric solutions. Drug Dev Ind Pharm 1983; 9(5): 861-875.
4. Sarisuta N, Parrott EL. Theoretical relationship between the dissolution rate and the bulk viscosity in polymeric solutions. Mahidol Univ J Pharm Sci 1983; 10(2): 49-53.
5. Sarisuta N, Siripraiwan S, Chutnarongchai C, Pornthanachai, Watcharadilokkul T. Drug release from ethylcellulose-glyceryl monostearate coated granules. Thai J Pharm Sci 1983; 8(4): 275-284.
6. Sarisuta N, Sirithunyalug J. Manufacture and release characteristics of indomethacin sustained release capsules. Mahidol Univ J Pharm Sci 1988; 15(3): 58-62.
7. Sarisuta N, Sirithunyalug J. Release rate of indomethacin from coated granules. Drug Dev Ind Pharm 1988; 14(5): 683-687.
8. Sarisuta N, Parrott EL. Effect of temperature, humidity, and aging on the disintegration and dissolution of acetaminophen tablets. Drug Dev Ind Pharm 1988; 14(13): 1877-1881.
9. Saowakonth R, Rungvejhavuttivittaya Y, Sarisuta N, Siripraiwan S, Suyanandana P. Formulation of sustained release mosquito larvicidal preparation from Bacillus sphaericus. Th J Pharm Sci 1993; 17(2): 73-77.
10. Sarisuta N, Jateleela S, Ruangsuksriwong C. Influence of surfactant on release of clonidine from ethylcellulose film. Asian J Pharm 1994; Congress Issue, 15th Asian Congress of Pharmaceutical Sciences, November: 183.
11. Sarisuta N, Thamsakdakorn T, Saowakonth R. Effect of temperature and humidity on physical properties of piroxicam tablets. In: Proceedings of the Second JSPS-NRCT Joint Seminar on “Recent Advances on Pharmaceutics and Pharmaceutical Technology”. Bangkok, Thailand: December 1994: OP33 (8 pages) (oral presentation).
12. Sarisuta N, Mahahpunt P. Effects of compression force and type of fillers on release of diclofenac sodium from matrix tablets. Drug Dev Ind Pharm 1994; 20(6): 1049-1061.
13. Sarisuta N, Punpreuk K. In vitro properties of film-coated diltiazem hydrochloride pellets compressed into tablets. J Cont Release 1994; 31: 215-222.
14. Sarisuta N, Tungjairukkandee S, Kraisintu, K. Physicochemical properties and stability of amphotericin B liposomes prepared by chloroform film method. In: Puttipipatkhachorn S, Sripha K, eds. Proceedings of the First Indochina Conference on Pharmaceutical Sciences (Pharma Indochina 1997) - Pharmacy in Harmony. Bangkok, Thailand: Faculty of Pharmacy, Mahidol University, May 1997: 93-97 (oral presentation).
15. Sarisuta N, Tourtip T, Chuarcharoern S. Chemical stability and mechanism of degradation of omeprazole in solution. Thai J Pharm Sci 1998; 22(2): 81-88.
16. Tourtip T, Wangwattana B, Srikul P, Sarisuta N. Instrumentation of adhesive strength measurement and effects of formulation factors on adhesive strength of film-coated tablets. Thai J Pharm Sci 1999; 23(2): 103-110.
17. Sarisuta N, Saowakontha R, Ruangsuksriwong C. Effects of surfactant on release characteristics of clonidine hydrochloride from ethylcellulose film. Drug Dev Ind Pharm 1999; 25(3): 373-377.
18. Sarisuta N, Thamsakdakorn T, Jateleela S. Effects of temperatur and humidity on the physical properties of piroxicam tablets. Pharm Tech 1999; 23(4) April: 66-80.
19. Sarisuta N, Thamsakdakorn T, Jateleela S. Effects of temperatur and humidity on the physical properties of piroxicam tablets. Pharm Tech Asia 1999; November: 6-13.
20. Sarisuta N, Kumpugdee M, Muller BW, Puttipipatkhachorn S. Physico-chemical characterization of interactions between erythromycin and various film polymers. Int J Pharm 1999; 186: 109-118.
21. Sarisuta N, Nooprasit I, Puttipipatkhachorn S. Active entrapment of amphotericin B liposomes utilizing lipid composition, surface charge of bilayers, and pH of hydration medium. Proceedings of the 18th Asian Congress of Pharmaceutical Sciences and 6th Pharmacy Australia Congress (FAPA-PAC Conference). Sydney, Australia: October 2000: IP-6 (oral presentation).
22. Sarisuta N, Tungjairukkandee S, Kraisintu, K. Physicochemical properties and stability of amphotericin B liposomes prepared by chloroform film method. Thai J Biotech 2000; 2(1): 39-48.
23. Sarisuta N,Kumpugdee M, Lawanprasert P. Physical structure characterization of theophylline in some acidic film-forming polymer. Drug Dev Ind Pharm 2000; 26(6): 687-691.
24. Sarisuta N,Kumpugdee M. Crystallinity of omeprazole in various film polymers. Pharm Pharmacol Commun 2000; 6: 7-11.
25. Sarisuta N, Jateleela S, Tourtip T. Dissolution kinetics of three-component compressed solid mixtures with largely different solubilities: Flaking spheres. J Pharm Sci 2000; 89(9): 1196-1211.
26. Pongjanyakul T, Prakongpan S, Priprem A, Sarisuta N. Lot-to-lot uniformity of acrylic-matrix-type nicotine transdermal patches. Proceedings of the Second indochina conference on pharmaceutical sciences (Pharma indochina II) – Indochina Pharmacy’s Advancement into the New Century. Hanoi, Vietnam: Hanoi College of Pharmacy, October 2001: 441-446.
27. Lawanprasert P, Pothikit S, Sarisuta N. Interaction of amphotericin B with plastic intravenous administration set. Mahidol Univ J Pharm Sci 2001; 28(1-4): 35-44.
28. Sarisuta N, Srikummoon K, Puttipipatkhachorn S. The influence of drug-polymer interactions on butt adhesive strength of film-coated tablets. Proceedings of the 4th World Meeting on Pharmaceutics , Biopharmaceutics and Pharmaceutical Technology, 8-11 April 2002, Florence, Italy (poster presentation).
29. Sarisuta N, Puangket S, Puttipipatkhachorn S. Effect of surfactants on release kinetics and mechanism of release of acyclovir from ethylcellulose film. Proceedings of the 19th Asian Congress of Pharmaceutical Sciences (FAPA Congress). Seoul, Korea: October 2002: 222 (oral presentation).
30. Puttipipatkhachorn S, Ratananontachai S, Sarisuta N. Physical and drug permeability characteristics of chitosan-anionic polymer complex films. Proceedings of the 19th Asian Congress of Pharmaceutical Sciences (FAPA Congress). Seoul, Korea: October 2002: 218.
31. Rojanapanthu P, Sarisuta N, Srigrisanapol A. Physicochemical properties of tetracaine liposomes prepared by chloroform film method. Proceedings of the 19th Asian Congress of Pharmaceutical Sciences (FAPA Congress). Seoul, Korea: October 2002: 224.
32. Lawanprasert P, Lukkanatinaporn P, Sarisuta N. Permeability of silicone membrane to model solutes. Mahidol Univ J Pharm Sci 2002; 29(1-2): 45-48.
33. Polnok A, Leelamanit W, Sarisuta, N. N-trimethyl chitosan chloride nanoparticles as a carrier system for mucosal protein delivery. Proceedings of the 14th International Symposium on Microencapsulation. Singapore: September 2003: 38.
34. Puttipipatkhachorn S, Tunsutthipanon P, Phaechamud T, Sarisuta N. Controlled drug release by compressed barrier coating with chitosan. Proceedings of the 2nd Asian Particle Technology Symposium (APT 2003). Penang, Malaysia: December 2003: 407-413.
35. Rojanapanthu P, Sarisuta N, Chaturon K, Kraisintu K. Physicochemical properties of amphotericin B liposomes prepared by reverse-phase evaporation method. Drug Dev Ind Pharm 2003; 29(1): 31-37.
36. Lawanprasert P, Auychaipornlert S, Thisuphakorn P, Sarisuta N, Chindavijak B. Percutaneous absorption enhancement of acyclovir. Mahidol Univ J Pharm Sci 2003; 30(3): 17-24.
37. Sarisuta N, Suriyaphan A, Puttipipatkhachorn S, Paeratakul O. Physicochemical properties and stability of amphotericin B liposomes prepared by reverse-phase evaporation method. Proceedings of the International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2004. Nuremberg, Germany: March 2004: (oral presentation)
38. Kunastitchai S, Mueller BW, Sarisuta N. Preparation of miconazole liposomes using aerosol solvent extraction system (ASES) process. Proceedings of the 20th Asian Congress of Pharmaceutical Sciences (FAPA Congress). Bangkok, Thailand: November-December 2004 (poster presentation).
39. Polnok A, Borchard G, Verhoef JC, Sarisuta N, Junginger HE. Influence of methylation process on the degree of quaternization of N-trimethyl chitosan chloride. Eur. J. Pharm. Biopharm. 2004; 57: 77-83.
40. Polnok A, Verhoef JC, Borchard G, Sarisuta N, Junginger HE. In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels. Int. J. Pharm. 2004; 269: 303-310.
41. Sarisuta N, Pattanasriroj P, Lawanprasert P, Junyaprasert VB. Influence of drug-polymer interaction on release characteristics of diltiazem HCl matrix tablets. Proceedings of the 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2006. Geneva, Switzerland: March 2006: (oral preentation).
42. Kunastitchai S, Pichert L, Sarisuta N, Mueller BW. Physicochemical properties and stability of miconazole liposomes prepared via aerosol solvent extraction system (ASES) process. Proceedings of the 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2006. Geneva, Switzerland: March 2006: Poster # 64.
43. Sarisuta N, Koksri S, Chantasart D, Wittaya-areekul S. Physicochemical properties and stability of freeze-dried amphotericin B liposomes prepared by reverse-phase evaporation method. Proceedings of the 21st Asian Congress of Pharmaceutical Sciences (FAPA Congress). Yokohama, Japan: November 2006: IP-O-03, 194 (oral presentation).
44. Sarisuta N, Srikummoon K, Lawanprasert P, Puttipipatkhachorn S. The influence of drug-excipient and drug-polymer interactions on butt adhesive strength of ranitidine hydrochloride film-coated tablets. Drug Dev Ind Pharm 2006; 32: 463-471.
45. Kunastitchai S, Pichert L, Sarisuta N, Mueller BW. Application of aerosol solvent extraction system (ASES) process for preparation of liposomes in a dry and reconstitutable form. Int J Pharm 2006; 316: 93-101.
46. Sarisuta N. Drug-polymer interactions: profound factors affecting end-use properties of drug delivery systems. Proceedings of the 2007 US-Thai Consortium Conference and Meeting. Bangkok, Thailand: January 2007: (Plenary lecture).
47. Sarisuta N. Liposomes of antimicrobial agents: from classical to novel techniques, physicochemical properties and stability. Proceedings of the Collaborative Research Network Conference on Nanomedicines. Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand: February 2007: 1-7 (Special lecture).
48. Kunastitchai S, Pichert L, Sarisuta N, Mueller BW. Drug solubility in phospholipid carrier as a predictive parameter for drug recovery in microparticles produced by the aerosol extraction system (ASES) process. Drug Dev Ind Pharm 2007; 33: 932-944.
49. Kunastitchai S, Panyarachun B, Mueller BW, Sarisuta N. Physical and chemical Stability of miconazole liposomes prepared by supercritical aerosol solvent extraction system (ASES) Process. Pharm Dev Technol 2007; 12: 361-370.
50. Kunastitchai S, Panyarachun B, Mueller BW, Sarisuta N. Physical and chemical Stability of miconazole liposomes prepared by supercritical aerosol solvent extraction system (ASES) Process. Pharm Dev Technol 2007; 12: 361-370.
51. Noomwong P, Ratanasak W, Sarisuta N. Enhancement of in vivo transcorneal permeability of acyclovir-loaded poly-lactic acid and bovine serum albumin nanoparticles. Proceedings of the 5th Indochina Conference on Pharmaceutical Sciences (Pharma Indochina 2007). Bangkok, Thailand: November 2007: PH-P-38 (6 pages) (poster presentation).
52. Sarisuta N, Pukanud P, Peungvicha P. Development of mannosylated acyclovir liposomes for in vitro absorption enhancement of oral drug delivery. Proceedings of the 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2008. Barcelona, Spain: April 2008: Poster # 130.
53. Witoonsaridsilp W, Sarisuta S, Mueller-Goymann CC. Nuclear magnetic resonance studies on the interaction between lysozyme and phospholipid vesicles. Proceedings of the 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2008. Barcelona, Spain: April 2008: Poster # 131.
54. Kongkaneramit L, Sarisuta N, Azad N, Lu Y, Iyer AKV, Wang L, Rojanasakul Y. Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial cells. J Pharmacol Exp Ther 2008; 325(3): 969-977.
55. Sarisuta N. Development and manufacture of liposomes of antifungal drugs: from classical to novel techniques. Proceedings of the 22nd Federation of Asian Pharmaceutical Associations Congress (FAPA 2008). Singapore: November 7-10, 2008: IP001, 81 (Ishidate Awardee Presentation).
56. Pooponpun S, Sarisuta N, Lawanprasert P. The mechanical and adhesion properties of film coats of cellulose derivatives containing some solid additives. Proceedings of the 22nd Federation of Asian Pharmaceutical Associations Congress (FAPA 2008). Singapore: November 7-10, 2008: IDP005, 302 (poster presentation).
57. Saraya S, Kanta, J, Sarisuta N, Temsiririrkkul R, Suvathi Y, Samranri K, Chumnumwat S. Development of Guava extract chewable tablets for anticariogenic activity against Streptococcus mutans. Mahidol Univ J Pharm Sci 2008; 35(1-4): 18-23.
58. Pukanud P, Peungvicha P, Sarisuta N. Development of mannosylated liposomes for bioadhesive oral drug delivery via M cells of Peyer’s patches. Drug Delivery 2009; 16(5): 289-294.
59. Witoonsaridsilp W, Panyarachun B, Sarisuta N, Mueller-Goymann CC. Influence of microenvironment and liposomal formulation on secondary structure and bilayer interaction of lysozyme. Colloid Surf. B 2010; 75(2): 501-509.
60. Kongkaneramit L, Witoonsaridsilp W, Peungvicha P, Sarisuta N. Antioxidant activity and cytotoxicity of different fractions from successive extraction of Asparagus racemosus. Proceedings of the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2010. Valletta, Malta: March 8-11, 2010 (poster presentation).
61. Sarisuta N. Development and manufacture of novel targeted drug delivery systems. The 1st UKM-MU Joint Scientific Conference 2010. Kuala Lumpur, Malaysia: October 12-13, 2010 (plenary lecture).
62. Jateleela S, Mitrevej A, Sarisuta N. Kinetic release of diltiazem hydrochloride from hydrophilic swellable matrices. Proceedings of the 23rd Federation of Asian Pharmaceutical Associations Congress (FAPA 2010). Taipei, Taiwan: November 5-8, 2010: P2H531, 801 (poster presentation).
63. Benjakul R, Müller-Goymann CC, Moongkarndi P, Sarisuta N. Development of α-mangostin-loaded liposomes: physicochemical properties and cytotoxicity effect. Proceedings of the 7th Indochina Conference on Pharmaceutical Sciences (Pharma Indochina 2011). Bangkok, Thailand: December 2010: OR-PD-02 (oral presentation).
64. Kongkaneramit L, Witoonsaridsilp W, Peungvicha P, Ingkaninan K, Waranuch N, Sarisuta N. Antioxidant activity and antiapoptotic effect of Asparagus racemosus root extracts in human lung epithelial H460 cells. Exp Ther Med 2011; 2: 143-148.
65. Benjakul B, Panyarachun B, Sarisuta N. Preparation of dry reconstitute liposomal powder by freeze-drying at room temperature. J Liposome Res 2011; 21(1): 28-37.
66. Boonyapiwat B, Sarisuta N, Kunastitchai S. Characterization and in vitro evaluation of intestinal absorption of liposomes encapsulating zanamivir. Current Drug Delivery 2011; 8(4): 392-397.
67. Boonyapiwat B, Sarisuta N, Ma Y, Steventon GB. A validated HPLC method for zanamivir and its application to in vitro permeability study in Caco-2 culture model. Indian J Pharm Sci 2011; 73(5): 483-596.
68. Benjakul R, Moongkarndi P, Panyarachun B, Sarisuta N. Novel freeze-drying method for preparation of alpha-mangostin dry reconstitute liposomal powder. Adv Sci Lett 2012; 11(1): 120-125.
69. Witoonsaridsilp W, Paeratakul O, Panyarachun B, Sarisuta N. Development of mannosylated liposomes using synthesized N-octadecyl-D-mannopyranosylamine to enhance gastrointestinal permeability for protein delivery. AAPS PharmSciTech 2012; 13(2): 699-706.
70. Tantisripreecha C, Jaturanpinyo M, Panyarachun B, Sarisuta N. Development of delayed-release proliposomes tablets for oral protein drug delivery. Drug Dev Ind Pharm 2012; 38(6): 718-727.
71. Witoonsaridsilp W, Panyarachun B, Sarisuta N. Development and characterization of mannosylated liposomes with synthesized Noctadecyl-D-mannopyranosylamine for oral protein delivery. Proceedings of the 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2012. Istanbul, Turkey: March 19-22, 2012 (poster presentation).
72. Witoonsaridsilp W, Panyarachun B, Jaturanpinyo M, Sarisuta N. Phospholipid vesicle–bound lysozyme to enhance permeability in human intestinal cells. Pharm Dev Tech 2012; Early Online: 1–7.

 

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